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Observe Carefully (one)pentobarbital will minimize the extent or result of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to a reduce in fentanyl plasma concentrations, insufficient efficacy or, maybe, enhancement